Dapagliflozin attenuates diabetic renal fibrosis by inhibiting macrophage-myofibroblast transition via the TGF-β1-Smad3/7 pathway

Objective Renal fibrosis plays a pivotal role in the progression of renal dysfunction in diabetic kidney disease (DKD), with the macrophage-to-myofibroblast transition (MMT) serving as a central mechanism driving the advancement of renal fibrosis to end-stage renal disease (ESRD) in various chronic...

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Hlavní autoři:	Xiaoyun Li, Guoxiang Yao, Honggang Wang, Tingting Zhao, Yujiao Sun, Qi Gao, Zhuo Li, Bing Chen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	PeerJ Inc. 2026-06-01
Edice:	PeerJ
Témata:	Diabetic kidney disease Dapagliflozin Renal fibrosis Macrophage-myofibroblast transition (MMT) TGF-β1/Smad
On-line přístup:	https://peerj.com/articles/21321.pdf
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