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Modeling lung adenocarcinoma metastases using patient-derived organoids

Summary: Approximately 50% of patients with surgically resected early-stage lung cancer develop distant metastasis. At present, there is no in vivo metastasis model to investigate the biology of human lung cancer metastases. Using well-characterized lung adenocarcinoma (LUAD) patient-derived organoi...

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Hlavní autoři: Yuan Liu, Manendra Lankadasari, Joel Rosiene, Kofi E. Johnson, Juan Zhou, Samhita Bapat, Lai-Fong L. Chow-Tsang, Huasong Tian, Brooke Mastrogiacomo, Di He, James G. Connolly, Harry B. Lengel, Raul Caso, Elizabeth G. Dunne, Cameron N. Fick, Gaetano Rocco, Smita Sihag, James M. Isbell, Mathew J. Bott, Bob T. Li, Piro Lito, Cameron W. Brennan, Mark H. Bilsky, Natasha Rekhtman, Prasad S. Adusumilli, Marty W. Mayo, Marcin Imielinski, David R. Jones
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2024-10-01
Edice:Cell Reports Medicine
Témata:
patient-derived organoids
lung adenocarcinoma
in vivo LUAD metastasis
tumor evolution
metastasis marker
drug resistance
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2666379124005226
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