The third signal cytokine IL-12 rescues the anti-viral function of exhausted HBV-specific CD8 T cells.

Optimal immune activation of naïve CD8 T cells requires signal 1 mediated by the T cell receptor, signal 2 mediated by co-stimulation and signal 3 provided by pro-inflammatory cytokines. However, the potential for signal 3 cytokines to rescue anti-viral responses in functionally exhausted T cells ha...

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Auteurs principaux:	Anna Schurich, Laura J Pallett, Marcin Lubowiecki, Harsimran D Singh, Upkar S Gill, Patrick T Kennedy, Eleni Nastouli, Sudeep Tanwar, William Rosenberg, Mala K Maini
Format:	Artigo
Langue:	Inglês
Publié:	Public Library of Science (PLoS) 2013-03-01
Collection:	PLoS Pathogens
Accès en ligne:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23516358/?tool=EBI
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