Cryo-EM structures of CRAF/MEK1/14-3-3 complexes in autoinhibited and open-monomer states reveal features of RAF regulation

Abstract CRAF (RAF1) is one of three RAF-family kinases that initiate MAP kinase signaling in response to activated RAS and is essential for oncogenic signaling from mutant KRAS. Like BRAF, CRAF is regulated by 14-3-3 engagement and by intramolecular autoinhibitory interactions of its N-terminal reg...

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Principais autores:	Dong Man Jang, Kayla Boxer, Byung Hak Ha, Emre Tkacik, Talya Levitz, Shaun Rawson, Rebecca J. Metivier, Anna Schmoker, Hyesung Jeon, Michael J. Eck
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2025-09-01
Serija:	Nature Communications
Online dostop:	https://doi.org/10.1038/s41467-025-63227-2
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