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Development, propagation and characterization of human somatic cell-derived bronchial organoids as model system for airway diseases – A practical guide

Human bronchial organoids represent a highly advanced 3D cell culture model system that reflects complex features of the airway epithelium, including structure, developmental aspects, tissue-specific functions and heterogeneous cell-cell interactions. Thus, they serve as an ideal model to study phys...

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Principais autores: Laura Kühl, Ariana Carvalho, Nicole Löwer, Sarah Miethe, Kim Pauck, Katrin Roth, Nele von Daacke, Pauline Graichen, Eva Müßig, Emma Huy, Anne Mende, Annika Block, Melanie Bachl, Jan Henrik Pflugmacher, Paul Dechert, Daniel P. Potaczek, Atefeh Sadeghi Shermeh, Holger Garn
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-06-01
coleção:Frontiers in Allergy
Assuntos:
3D cell culture model system
air-liquid interface (ALI) cultures
airway diseases
airway epithelium
bronchial organoids
human lung organoids
Acesso em linha:https://www.frontiersin.org/articles/10.3389/falgy.2026.1811482/full
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