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REST-driven upregulation of SFXN3 promotes AML progression via Wnt/β-catenin activation and confers decitabine resistance

One of the most diverse types of blood cancer is acute myeloid leukemia, or AML, and there remains an urgent need to identify novel molecular targets for its diagnosis and treatment. The present investigation identified Sideroflexin 3 (SFXN3) as a possible prognostic biomarker in AML by integrating...

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Autori principali: Xiaoling Wang, Youcai Huang, Mingwei Sun, Shuyi Cai, Xiaoyu Hu, Yi Zheng, Shumin Fang, Sumei Li, Yanyang Tu, Huanwen Tang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2026-04-01
Serie:Translational Oncology
Soggetti:
SFXN3
REST
Acute myeloid leukemia
Wnt/β-catenin signaling
Prognostic biomarker
Decitabine sensitivity
Accesso online:http://www.sciencedirect.com/science/article/pii/S1936523326000422
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