Dual CDK2 and CDK4/6 inhibition suppresses Rb/E2F signaling and enhances anti-leukemic activity in acute myeloid leukemia

The cyclin-dependent kinase 6 (CDK6) is a central regulator of cell cycle progression and an important contributor to the development of acute leukemia, particularly in poor prognosis subtypes. Preclinical studies have demonstrated activity of CDK6-targeting drugs in acute myeloid leukemia (AML) an...

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Principais autores:	Ellen Weisberg, Basudev Chowdhury, Swati Garg, Taisei Akatsu, Wei Ni, Prafulla C. Gokhale, Benjamin K. Eschle, Sydney Grant, Martin Sattler, James A. DeCaprio, Lukas Nöltner, Jacqueline Garcia, Kate Marinchev, Ilene Galinsky, Aritro Nath, Richard M. Stone, James D. Griffin
格式:	Artigo
語言:	Inglês
出版:	Ferrata Storti Foundation 2026-06-01
叢編:	Haematologica
在線閱讀:	https://haematologica.org/article/view/14240
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