Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block

A novel consecutive three-component synthesis of 3-(hetero)aryl-1H-pyrazoles via room temperature Sonogashira arylation of propynal diethylacetal used as a propargyl aldehyde synthetic equivalent has been disclosed. The final acetal cleavage-cyclocondensation with hydrazine hydrochloride at 80 °C ra...

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Главные авторы:	Thomas J. J. Müller, Eugen Merkul, Charlotte F. Gers, Christina Boersch, Lucilla Levi
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2011-11-01
Серии:	Molecules
Предметы:	alkyne cyclocondensation multi-component reaction pyrazole Sonogashira coupling
Online-ссылка:	http://www.mdpi.com/1420-3049/16/11/9340/
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