Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics
Here the authors use chemical proteomics to identify the herpes simplex virus 1 encoded proteome in infected cells. Functional characterization of one of the nine identified proteins, designated piUL49, shows that it acts as neurovirulence factor in mice by regulating a virally encoded dUTPase.
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| Autori principali: | , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2020-09-01
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| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-020-18718-9 |
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