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Effect of Experimental Electrical and Biological Parameters on Gene Transfer by Electroporation: A Systematic Review and Meta-Analysis

The exact mechanisms of nucleic acid (NA) delivery with gene electrotransfer (GET) are still unknown, which represents a limitation for its broader use. Further, not knowing the effects that different experimental electrical and biological parameters have on GET additionally hinders GET optimization...

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Main Authors: Tjaša Potočnik, Alenka Maček Lebar, Špela Kos, Matej Reberšek, Eva Pirc, Gregor Serša, Damijan Miklavčič
Format: Artigo
Language:Inglês
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
gene electrotransfer
plasmid DNA
nucleic acid
pulse parameters
electroporation medium
cell line
Online Access:https://www.mdpi.com/1999-4923/14/12/2700
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