Variability vs. phenotype: Multimodal analysis of Dravet syndrome brain organoids powered by deep learning

Summary: Dravet syndrome (DS) is a developmental epileptic encephalopathy (DEE) driven by pathogenic variants in the SCN1A gene. Brain organoids (BOs) have emerged as reliable models for neurodevelopmental genetic disorders, reproducing human brain developmental milestones and rising as a promising...

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Bibliografiske detaljer

Principais autores:	Isabel Turpin-Moreno, Adriana Modrego, Andrea Martí-Sarrias, Laura García-González, Alba Ortega-Gasco, Anna-Christina Haeb, Ruth Pareja, Jordi Soriano, Núria Ruiz, Irene Peñuelas-Haro, Elisa Espinet, Arcadi Navarro, Daniel Tornero, Oscar Lao, Sandra Acosta
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2025-11-01
Serier:	iScience
Fag:	artificial intelligence biological sciences neuroscience optical imaging techniques in neuroscience
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2589004225020929
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