Causal relevance of the JAK/STAT pathway for cardioprotection via cold acclimation

Abstract Cardioprotective effect of cold acclimation (5 weeks; 9 °C; CA) and the same effect persisting 2 weeks after recovery from CA (CAR) are induced by different mechanisms. We showed that salvage β2-adrenoceptor/Gi/Akt pathway is only involved in the mechanism of cardioprotection after CAR. Sin...

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Principais autores:	Petr Kasik, Frantisek Galatik, Petr Matous, Petr Paral, Daniel Vasek, Daniela Horníkova, Barbara Elsnicova, Jitka M. Zurmanova
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2026-03-01
Series:	Scientific Reports
Assuntos:	Cardioprotection Cold acclimation Mitochondria MPT pore JAK2/STAT3 pathway Cytokine
Acceso en liña:	https://doi.org/10.1038/s41598-026-40532-4
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