Engineering Saccharomyces cerevisiae for the de novo Production of Halogenated Tryptophan and Tryptamine Derivatives

Abstract The indole scaffold is a recurring structure in multiple bioactive heterocycles and natural products. Substituted indoles like the amino acid tryptophan serve as a precursor for a wide range of natural products with pharmaceutical or agrochemical applications. Inspired by the versatility of...

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Hauptverfasser:	Dr. Nicholas Milne, Javier Sáez‐Sáez, Annette Munch Nielsen, Dr. Jane Dannow Dyekjær, Dr. Daniela Rago, Dr. Mette Kristensen, Dr. Tune Wulff, Prof. Dr. Irina Borodina
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley-VCH 2023-04-01
Schriftenreihe:	ChemistryOpen
Schlagworte:	halogenases indole in vivo halogenation metabolic engineering Saccharomyces cerevisiae
Online-Zugang:	https://doi.org/10.1002/open.202200266
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