Pathogenic LRRK2 mutations cause loss of primary cilia and Neurturin in striatal parvalbumin interneurons
Parvalbumin interneurons in the dorsal striatum lose primary cilia in mice and humans harboring Parkinson’s disease–associated, activating mutations in LRRK2 kinase, resulting in loss of hedgehog signaling and decreased production of neuroprotective Neurturin to support dopamine neurons. Parkinson’s...
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| Principais autores: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Life Science Alliance LLC
2025-01-01
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| Serija: | Life Science Alliance |
| Online dostop: | https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202402922 |
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