SLFN11 counteracts the RFWD3-PRIMPOL DNA damage tolerance axis to restrain gapped DNA synthesis in response to replication stress

Abstract Schlafen family member 11 (SLFN11) expression sensitizes cells to a spectrum of DNA-damaging chemotherapies. Previous studies have shown that SLFN11 is recruited to stalled replication forks in response to replication stress; however, the role of SLFN11 at stressed replication forks remains...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Kate E. Coleman, Dong-Woo Shin, Liana Goehring, Beata Szeitz, David Fenyö, Eli Rothenberg, John T. Poirier, Tony T. Huang
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2025-12-01
Цуврал:	Nature Communications
Онлайн хандалт:	https://doi.org/10.1038/s41467-025-66068-1
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!