Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function

Genetic variation at the MTIF3 (Mitochondrial Translational Initiation Factor 3) locus has been robustly associated with obesity in humans, but the functional basis behind this association is not known. Here, we applied luciferase reporter assay to map potential functional variants in the haplotype...

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Hlavní autoři:	Mi Huang, Daniel Coral, Hamidreza Ardalani, Peter Spegel, Alham Saadat, Melina Claussnitzer, Hindrik Mulder, Paul W Franks, Sebastian Kalamajski
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	eLife Sciences Publications Ltd 2023-03-01
Edice:	eLife
Témata:	obesity CRISPR eQTL adipocyte
On-line přístup:	https://elifesciences.org/articles/84168
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