Hypoxia Affects Stem Cell Fate in Patient-Derived Ileum Enteroids in a HIF-1α-Dependent Manner

The intestinal epithelium maintains tissue homeostasis through a dynamic balance of stem cell proliferation and differentiation. This process is spatially regulated along the crypt–villus axis, with intestinal stem cells in the crypt regions proliferating and progenitor cells differentiating as they...

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Egile Nagusiak:	Zina M. Uckeley, Carmon Kee, Carlos Ramirez, Victoria Karaluz, Ashwini K. Sharma, Josmar Polanco, Freddie D. Ortiz Martinez, Christopher I. Mederos, Sorin O. Jacobs, Ingrid J. Groose, James M. Ramsden, Carl Herrmann, Megan L. Stanifer, Steeve Boulant
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2025-12-01
Saila:	Cells
Gaiak:	hypoxia organoid formation enteroids ileum intestinal stem cells epithelium
Sarrera elektronikoa:	https://www.mdpi.com/2073-4409/15/1/31
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