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Inhibition of Autophagy by Chloroquine Stimulates Nitric Oxide Production and Protects Endothelial Function during Serum Deprivation

Background/Aims: Autophagy plays a fundamental role in cell survival under stress conditions such as nutrient deprivation. Decreased nitric oxide (NO) production, which may contribute to vascular dysfunction, is one of the consequences of autophagy in endothelial cells. The antimalarial drug chloroq...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Cezar Rangel Pestana, Jorge Camargo Oishi, Heloísa Sobreiro Salistre-Araújo, Gerson Jhonatan Rodrigues
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Physiol Biochem Press GmbH & Co KG 2015-09-01
Schriftenreihe:Cellular Physiology and Biochemistry
Schlagworte:
Nitric oxide
Autophagy
Chloroquine
Vascular reactivity
Vasorelaxation
Endothelium
Online-Zugang:http://www.karger.com/Article/FullText/430240
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