Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells

In the context of adoptive T cell transfer (ACT) for cancer treatment, it is crucial to generate in vitro large amounts of tumor-specific CD8 T cells with high potential to persist in vivo. PD-1, Tim3, and CD39 have been proposed as markers of tumor-specific tumor-infiltrating CD8 T lymphocytes (CD8...

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Principais autores:	Amaia Martinez-Usatorre, Santiago J. Carmona, Céline Godfroid, Céline Yacoub Maroun, Sara Labiano, Pedro Romero
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-02-01
coleção:	Frontiers in Immunology
Assuntos:	tumor-infiltrating CD8 T cells precursor exhausted T cells memory-like CD8 T cells adoptive cell transfer melanoma
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2020.00340/full
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