Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect

Abstract Background MEK1 mutation and activated MAPK signaling has been found in patients with RASopathies and abnormal cardiac development. Previous studies have suggested that regulation of fetal MAPK signaling is essential for normal cardiac development. We investigated the effect of active MEK1...

Descripció completa

Dades bibliogràfiques

Autors principals:	Che-Chung Yeh, Yanying Fan, Yi-Lin Yang, Michael J. Mann
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2017-11-01
Col·lecció:	Journal of Biomedical Science
Matèries:	Atrial septal defect RASopathies Mitogen-activated protein kinase MAP kinase phosphatase Mitogen-activated protein kinase pathway
Accés en línia:	http://link.springer.com/article/10.1186/s12929-017-0392-2
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!