Effects of arsenic on the topology and solubility of promyelocytic leukemia (PML)-nuclear bodies.
Promyelocytic leukemia (PML) proteins are involved in the pathogenesis of acute promyelocytic leukemia (APL). Trivalent arsenic (As3+) is known to cure APL by binding to cysteine residues of PML and enhance the degradation of PML-retinoic acid receptor α (RARα), a t(15;17) gene translocation product...
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| Principais autores: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science (PLoS)
2022-01-01
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| Serier: | PLoS ONE |
| Online adgang: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0268835&type=printable |
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