Integrating single-cell and spatial transcriptomics to reveal the spatiotemporal dynamics of retinal cells during ischemia–reperfusion injury progression in rats

Abstract Retinal ischemia–reperfusion (I/R) injury is a key pathological process in retinal-associated diseases such as glaucoma. However, the spatiotemporal dynamics and cell interactions during this injury are not fully understood. This study integrated single-cell RNA sequencing and spatial trans...

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Główni autorzy:	Yijia Huang, Junhong Guo, Fei Yao, Bingkai Feng, Di Gong, Kuanrong Dang, Tingyu Hu, Simin Deng, Yong Liu, Chunyan Tan, Jiantao Wang
Format:	Artigo
Język:	Inglês
Wydane:	BMC 2026-04-01
Seria:	Cell & Bioscience
Hasła przedmiotowe:	Retinal ischemia–reperfusion injury Spatial transcriptome sequencing Single-cell transcriptome sequencing Cell and tissue heterogeneity Glaucoma
Dostęp online:	https://doi.org/10.1186/s13578-026-01571-6
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