Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation

Abstract Emerging evidence suggests that Nrf2 plays a pro‐carcinogenic role in multiple cancers. Previous studies have shown that arsenic‐induced Nrf2 activation drives metabolic reprogramming, leading to the formation of cancer stem‐like cells. Here, we further demonstrate that KLF4, a key pluripot...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Wiley 2025-10-01
Sarja:	Advanced Science
Aiheet:	arsenic carcinogenesis cell malignancy KLF4 Nrf2
Linkit:	https://doi.org/10.1002/advs.202500221
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