Autologous humanized mouse models to study combination and single-agent immunotherapy for colorectal cancer patient-derived xenografts

Designing studies of immunotherapy is limited due to a lack of pre-clinical models that reliably predict effective immunotherapy responses. To address this gap, we developed humanized mouse models of colorectal cancer (CRC) incorporating patient-derived xenografts (PDX) with human peripheral blood m...

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Detalhes bibliográficos

Principais autores:	Preeti Kanikarla Marie, Alexey V. Sorokin, Lea A. Bitner, Rebecca Aden, Michael Lam, Ganiraju Manyam, Melanie N. Woods, Amanda Anderson, Anna Capasso, Natalie Fowlkes, Michael J. Overman, David G. Menter, Scott Kopetz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-09-01
coleção:	Frontiers in Oncology
Assuntos:	humanized mice immunotherapy colorectal cancer pre-clinical studies T cells
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2022.994333/full
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