Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

The Keap1–Nrf2–ARE pathway is an important antioxidant defense mechanism that protects cells from oxidative stress and the Keap1–Nrf2 protein–protein interaction (PPI) has become an important drug target to upregulate the expression of ARE-controlled cytoprotective oxidative stress response enzymes...

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Autori principali:	Dhulfiqar Ali Abed, Melanie Goldstein, Haifa Albanyan, Huijuan Jin, Longqin Hu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2015-07-01
Serie:	Acta Pharmaceutica Sinica B
Soggetti:	Oxidative stress Keap1 Nrf2 Direct inhibitors of protein–protein interaction High throughput screening assays Structure–activity relationships X-ray crystallography
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211383515000829
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