Ex vivo effects of low dose delayed release rapamycin on agonist-induced platelet aggregation, activation and procoagulant platelet phenotypes in domestic cats

Abstract Cardiogenic arterial thromboembolism (CATE) is a complication of cardiac diseases with a high mortality rate. Despite anti-platelet drugs use, on-treatment recurrence rate remains high indicating a critical need to discover novel therapies. Studies in both humans and cats show that low dose...

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Hlavní autoři:	Meg Shaverdian, Nghi Nguyen, Stuart Fitzgerald, Louise Grubb, Joshua A. Stern, Ronald H. L. Li
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-04-01
Edice:	Scientific Reports
Témata:	Rapamycin Procoagulant platelets Cardiogenic arterial thromboembolism Hypertrophic cardiomyopathy Mitochondrial membrane potential Phosphatidylserine
On-line přístup:	https://doi.org/10.1038/s41598-026-46991-z
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