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Biochemical Characterization and Synthetic Application of WciN and Its Mutants From Streptococcus pneumoniae Serotype 6B

The biochemical properties of α-1,3-galactosyltransferase WciN from Streptococcus pneumoniae serotype 6B were systemically characterized with the chemically synthesized Glcα-PP-(CH2)11-OPh as an acceptor substrate. The in vitro site-directed mutation of D38 and A150 residues of WciN was further inve...

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Main Authors: Wei Gong, Min Liang, Jielin Zhao, Hong Wang, Zonggang Chen, Fengshan Wang, Guofeng Gu
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Chemistry
Subjects:
Streptococcus pneumoniae serotype 6B
capsular polysaccharides
galactosyltransferase
site mutation
enzymatic synthesis
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.914698/full
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