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Structure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s

Passive transfer of monoclonal antibodies (mAbs) of human origin into Non-Human Primates (NHPs), especially those which function predominantly by a Fc-effector mechanism, requires an a priori preparation step, in which the human mAb is reengineered to an equivalent NHP IgG subclass. This can be achi...

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Principais autores: William D. Tolbert, Dung N. Nguyen, Marina Tuyishime, Andrew R. Crowley, Yaozong Chen, Shalini Jha, Derrick Goodman, Valerie Bekker, Sarah V. Mudrak, Anthony L. DeVico, George K. Lewis, James F. Theis, Abraham Pinter, M. Anthony Moody, David Easterhoff, Kevin Wiehe, Justin Pollara, Kevin O. Saunders, Georgia D. Tomaras, Margaret Ackerman, Guido Ferrari, Marzena Pazgier
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-01-01
coleção:Frontiers in Immunology
Assuntos:
antibody engineering
rhesusization
Fc-effector function
non-human primates
HIV
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2021.787603/full
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