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Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis

The quest to extend healthspan via pharmacological means is becoming increasingly urgent, both from a health and economic perspective. Here we show that lithium, a drug approved for human use, promotes longevity and healthspan. We demonstrate that lithium extends lifespan in female and male Drosophi...

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Main Authors: Jorge Iván Castillo-Quan, Li Li, Kerri J. Kinghorn, Dobril K. Ivanov, Luke S. Tain, Cathy Slack, Fiona Kerr, Tobias Nespital, Janet Thornton, John Hardy, Ivana Bjedov, Linda Partridge
Format: Artigo
Language:Inglês
Published: Elsevier 2016-04-01
Series:Cell Reports
Subjects:
GSK-3
NRF-2
aging
xenobiotic stress
Keap1
dietary restriction
triglycerides
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716302972
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