Structure-guided virtual screening reveals phytoconstituents as potent cathepsin B inhibitors: Implications for cancer, traumatic brain injury, and Alzheimer’s disease

Cathepsin B (CathB) is a lysosomal cysteine protease involved in various pathological and physiological processes and is becoming an attractive target for drug intervention in complex diseases like cancer, traumatic brain injury (TBI) and Alzheimer’s disease (AD). The aberrant expression of CathB dr...

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Autors principals:	Nageeb Hassan, Mohammad Furkan, Mohd Shahnawaz Khan, Azna Zuberi, Moyad Shahwan, Anas Shamsi
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-04-01
Col·lecció:	Frontiers in Molecular Biosciences
Matèries:	cathepsin B cancer traumatic brain injury Alzheimer’s disease drug discovery virtual screening hERG blocker hepatotoxicity
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fmolb.2025.1581711/full
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