Quantitative analysis of myeloid cell patterns and immunosuppressive enzyme (IDO, ARG1) expression in colorectal cancer pulmonary metastases and corresponding primary tumours

Abstract Indoleamine-2,3-dioxygenase (IDO) and arginase1 (ARG1) are immunosuppressive enzymes frequently overexpressed in cancer, with higher expression in colorectal cancer primary tumours paradoxically linked to favourable survival. Their significance in metastases remains unexplored. Employing mu...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Topias Karjula, Hanna Elomaa, Sara A. Väyrynen, Vesa-Matti Pohjanen, Maarit Ahtiainen, Jan Böhm, Jukka-Pekka Mecklin, Erkki-Ville Wirta, Toni T. Seppälä, Eero Sihvo, Fredrik Yannopoulos, Olli Helminen, Juha P. Väyrynen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-03-01
coleção:	Scientific Reports
Assuntos:	Pulmonary metastases Colorectal cancer Cancer immunology Myeloid cells IDO ARG1
Acesso em linha:	https://doi.org/10.1038/s41598-026-42097-8
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!