Exploring Candesartan, an angiotensin II receptor antagonist, as a novel inhibitor of NLRP3 inflammasome: alleviating inflammation in Neisseria gonorrhoeae infection

Abstract Background Gonorrhea, induced by Neisseria gonorrhoeae infection, stands as a prevalent sexually transmitted inflammatory disease globally. Our earlier research illuminated that N. gonorrhoeae-infected macrophages provoke inflammation by activating the intracellular sensor NACHT, LRR, and P...

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Principais autores:	Wen-Yu Lin, Jin-Lian Tsui, Hsiao-Wen Chiu, Wei-Ting Wong, Chun‑Hsien Wu, Hsien-Ta Hsu, Chen-Lung Ho, Shan-Pei Yeh, Yerra Koteswara Rao, Ann Chen, Chien-Chun Wang, Chung-Hua Hsu, Oleg V. Chernikov, Kuo-Feng Hua, Lan-Hui Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-11-01
coleção:	BMC Infectious Diseases
Assuntos:	Angiotensin II receptor antagonist Candesartan NLRP3 inflammasome Neisseria gonorrhoeae
Acesso em linha:	https://doi.org/10.1186/s12879-024-10208-3
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