Tissue distribution and tumor uptake of folate receptor–targeted epothilone folate conjugate, BMS-753493, in CD2F1 mice after systemic administration

To assess targeting of an epothilone folate conjugate (BMS-753493) to the folate receptor (FR)-overexpressed tumor in mice bearing both FR+ and FR– tumors, a series of experiments were conducted by quantitative whole-body autoradiography (QWBA) and LC–MS/MS following i.v. administration of BMS-75349...

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Detalhes bibliográficos

Principais autores:	Hong Shen, Lifei Wang, Weiqi Chen, Krista Menard, Yang Hong, Yuan Tian, Samuel J. Bonacorsi, W. Griffith Humphreys, Francis Y. Lee, Jinping Gan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2016-09-01
Colecção:	Acta Pharmaceutica Sinica B
Assuntos:	Folate receptor Tumor selective targeting Folate receptor–expressing tumor Epothilone folate conjugate Tissue distribution Tumor uptake
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211383516301058
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