Cryo-EM structures of the CDK11-cyclin L-SAP30BP complex reveal mechanisms of CDK11 regulation

Abstract The cyclin-dependent kinase CDK11 functions in transcription, mitotic progression, and mRNA splicing. Specifically, spliceosome activation during the B to Bact transition depends on phosphorylation of the U2 snRNP component SF3B1 by the CDK11-cyclin L-SAP30BP complex. Here, we present the s...

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Autors principals:	Amy J. S. McGeoch, Victoria I. Cushing, Theodoros I. Roumeliotis, Nora B. Cronin, Stephen J. Hearnshaw, Jyoti S. Choudhary, Claudio Alfieri, Basil J. Greber
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-04-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-026-72329-4
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