Altering the carbohydrate-binding specificity of the legume lectin FRIL through structure-guided engineering

Abstract FRIL is a legume lectin from the hyacinth bean that has broad-spectrum antiviral activity. A distinctive trait of FRIL among similar mannose/glucose-specific legume lectins is that FRIL shows specificity for complex type N-glycans. We postulate that an extended binding site on FRIL facilita...

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Bibliografske podrobnosti

Principais autores:	Yo-Min Liu, Hong Thuy Vy Nguyen, Xiaorui Chen, Md. Shahed-Al-Mahmud, Ting-Hua Chen, Kuo-Shiang Liao, Jennifer M. Lo, Tzu-Chun Kan, Chien-Tai Ren, Che Ma
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2026-03-01
Serija:	Nature Communications
Online dostop:	https://doi.org/10.1038/s41467-026-70188-7
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