Regulator of G protein signaling 12 enhances osteoclastogenesis by suppressing Nrf2-dependent antioxidant proteins to promote the generation of reactive oxygen species

Regulators of G-protein Signaling are a conserved family of proteins required in various biological processes including cell differentiation. We previously demonstrated that Rgs12 is essential for osteoclast differentiation and its deletion in vivo protected mice against pathological bone loss. To c...

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Detalhes bibliográficos

Principais autores:	Andrew Ying Hui Ng, Ziqing Li, Megan M Jones, Shuting Yang, Chunyi Li, Chuanyun Fu, Chengjian Tu, Merry Jo Oursler, Jun Qu, Shuying Yang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2019-09-01
coleção:	eLife
Assuntos:	osteoclasts reactive oxygen species proteomics
Acesso em linha:	https://elifesciences.org/articles/42951
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