Development and Validation of a New LC-MS/MS Bioanalytical Method for the Simultaneous Determination of Levodopa, Levodopa Methyl Ester, and Carbidopa in Human Plasma Samples

Levodopa (L-DOPA) treatment, combined with the administration of dopa-decarboxylase inhibitors (DDCIs), is still the most effective symptomatic treatment of Parkinson’s disease (PD). Although its efficacy in the early stage of the disease has been confirmed, its complex pharmacokinetics (PK) increas...

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Ngā kaituhi matua:	Linda Molteni, Bruno Charlier, Viviana Izzo, Albino Coglianese, Valeria Conti, Roberto Eleopra, Roberto Cilia, Chiara Capelli, Annachiara D’Urso, Ugo de Grazia
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2023-05-01
Rangatū:	Molecules
Ngā marau:	levodopa levodopa methyl ester carbidopa Parkinson’s disease therapeutic drug monitoring liquid chromatography–mass spectrometry (LC–MS)
Urunga tuihono:	https://www.mdpi.com/1420-3049/28/11/4264
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!