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Emi2 Is Essential for Mouse Spermatogenesis

The meiotic functions of Emi2, an inhibitor of the APC/C complex, have been best characterized in oocytes where it mediates metaphase II arrest as a component of the cytostatic factor. We generated knockout mice to determine the in vivo functions of Emi2—in particular, its functions in the testis, w...

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Wedi'i Gadw mewn:
Prif Awduron: Lakshmi Gopinathan, Radoslaw Szmyd, Diana Low, M. Kasim Diril, Heng-Yu Chang, Vincenzo Coppola, Kui Liu, Lino Tessarollo, Ernesto Guccione, Ans M.M. van Pelt, Philipp Kaldis
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2017-07-01
Cyfres:Cell Reports
Pynciau:
knockout mice
Emi2
APC/C
meiosis
Cdk1
phosphorylation
spermatogenesis
diplotene
spermatocytes
ovary
Mynediad Ar-lein:http://www.sciencedirect.com/science/article/pii/S2211124717308471
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