TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency

Abstract To study whether TGF-β1/IL-11/MEK/ERK (TIME) signaling mediates senescence-associated pulmonary fibrosis (SAPF) in Bmi-1-deficient (Bmi-1−/−) mice and determines the major downstream mediator of Bmi-1 and crosstalk between p16INK4a and reactive oxygen species that regulates SAPF, phenotypes...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Haiyun Chen, Hongjie Chen, Jialong Liang, Xin Gu, Jiawen Zhou, Chunfeng Xie, Xianhui Lv, Rong Wang, Qing Li, Zhiyuan Mao, Haijian Sun, Guoping Zuo, Dengshun Miao, Jianliang Jin
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Publishing Group 2020-01-01
Цуврал:	Experimental and Molecular Medicine
Онлайн хандалт:	https://doi.org/10.1038/s12276-019-0371-7
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!