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Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase

Checkpoints maintain the order of cell cycle events during DNA damage or incomplete replication. How the checkpoint response is tailored to different phases of the cell cycle remains poorly understood. The S-phase checkpoint for example results in the slowing of replication, which in budding yeast o...

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Detalhes bibliográficos
Principais autores: Mark C Johnson, Geylani Can, Miguel Monteiro Santos, Diana Alexander, Philip Zegerman
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2021-01-01
Colecção:eLife
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Acesso em linha:https://elifesciences.org/articles/63589
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