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Brain-derived neurotrophic factor supports pericyte and vascular homeostasis in the aging brain

Abstract Microvascular circulation in the brain is often impaired in connection with the loss of pericytes in old age. The neurotrophic factor BDNF also decreases in the aging brain. We hypothesized that BDNF regulates the homeostasis of cerebral pericytes and microvasculature. We used differently a...

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Principais autores: Qinghua Luo, Wenqiang Quan, Qian Cao, Chris Scheffel, Wenlin Hao, Jing Yang, Tomomi Furihata, Guoping Peng, Zhenyu Tang, Yang Liu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-12-01
coleção:Acta Neuropathologica Communications
Assuntos:
Aging
BDNF
Microcirculation
And pericyte
Acesso em linha:https://doi.org/10.1186/s40478-025-02181-y
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