Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice

Alveolar epithelial cell (AEC) senescence is implicated in the pathogenesis of pulmonary fibrosis (PF). However, the exact mechanism underlying AEC senescence during PF remains poorly understood. Here, we reported an unrecognized mechanism for AEC senescence during PF. We found that, in bleomycin (B...

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Bibliografische Detailangaben

Hauptverfasser:	Jie-Ru Hong, Ling Jin, Chen-Yu Zhang, Wen-Jing Zhong, Hui-Hui Yang, Guan-Ming Wang, Sheng-Chao Ma, Cha-Xiang Guan, Qing Li, Yong Zhou
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2023-06-01
Schriftenreihe:	Heliyon
Schlagworte:	Citratemt accumulation Alveolar epithelial cell Senescence Pulmonary fibrosis Mitochondrial biogenesis
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2405844023045693
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