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Protein PEGylation for the design of biobetters: from reaction to purification processes

The covalent attachment of polyethylene glycol (PEG) to therapeutical proteins is an important route to develop biobetters for biomedical, biotech and pharmaceutical industries. PEG conjugation can shield antigenic epitopes of the protein, reduce degradation by proteolytic enzymes, enhance long-term...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: João Henrique Picado Madalena Santos, Karin Mariana Torres-Obreque, Giovanna Pastore Meneguetti, Beatriz Panichi Amaro, Carlota Oliveira Rangel-Yagui
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas 2018-11-01
Rangatū:Brazilian Journal of Pharmaceutical Sciences
Ngā marau:
PEGylation
Biobetters
Biological drugs
Polyethylene glycol
Protein purification
Site-specific PEGylation
Urunga tuihono:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000700408&lng=en&tlng=en
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