Stress-induced reversible cell-cycle arrest requires PRC2/PRC1-mediated control of mitophagy in Drosophila germline stem cells and human iPSCs

Summary: Following acute genotoxic stress, both normal and tumorous stem cells can undergo cell-cycle arrest to avoid apoptosis and later re-enter the cell cycle to regenerate daughter cells. However, the mechanism of protective, reversible proliferative arrest, “quiescence,” remains unresolved. Her...

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Bibliografische Detailangaben

Hauptverfasser:	Tommy H. Taslim, Abdiasis M. Hussein, Riya Keshri, Julien R. Ishibashi, Tung C. Chan, Bich N. Nguyen, Shuozhi Liu, Daniel Brewer, Stuart Harper, Scott Lyons, Ben Garver, Jimmy Dang, Nanditaa Balachandar, Samriddhi Jhajharia, Debra del Castillo, Julie Mathieu, Hannele Ruohola-Baker
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2023-01-01
Schriftenreihe:	Stem Cell Reports
Schlagworte:	mitochondria cyclin E mitophagy mTOR pluripotent stem cells epigenetic
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2213671122005379
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