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Multi-layer stratified oncology platform utilizing transcriptomics, prostate cancer organoids, and modeling of drug response

Abstract The high intra-patient heterogeneity in multifocal primary prostate cancer (PCa) has curtailed the efficacy of current treatment options. By employing twin biopsies from multiple lesions with matched patient-derived organoids (PDO) models, the PCa molecular heterogeneity was investigated. W...

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I tiakina i:
Ngā kaituhi matua: Juening Kang, Panagiotis Chouvardas, Andrew Maalouf, Daniel Hanhart, Laura Fernández Cerro, Wanli Cheng, Eva Compérat, Katja Ovchinnikova, Rahel Etter, Michaela Medová, Ulrich Schneeberger, Beat Roth, George N. Thalmann, Sofia Karkampouna, Marianna Kruithof-de Julio
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2025-10-01
Rangatū:Journal of Experimental & Clinical Cancer Research
Urunga tuihono:https://doi.org/10.1186/s13046-025-03540-2
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