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A positive feedback loop driven by fibronectin and IL-1β sustains the inflammatory microenvironment in breast cancer

Abstract Inflammatory alterations of the extracellular matrix shape the tumor microenvironment and promote all stages of carcinogenesis. This study aims to determine the impact of cellular fibronectin on inflammatory facets of tumor-associated macrophages (TAMs) in breast cancer. Cellular fibronecti...

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Principais autores: Gurcan Tunali, Hamdullah Yanik, Suleyman Can Ozturk, Secil Demirkol-Canli, Georgios Efthymiou, Kerim Bora Yilmaz, Ellen Van Obberghen-Schilling, Gunes Esendagli
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2023-03-01
סדרה:Breast Cancer Research
נושאים:
Fibronectin
Triple-negative breast cancer
Inflammation
Tumor-associated macrophage
STAT3
NF-κB
גישה מקוונת:https://doi.org/10.1186/s13058-023-01629-0
תגים: הוספת תג
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