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The improved synthesis of ROCKYPhos and its application for the asymmetric hydrogenation of dihydroisoquinoline derivatives

An optimized approach to the multigram synthesis of [(1R,2R,3S)-(+)-1,2-dimethyl-2,3-bis(diphenylphosphinomethyl)cyclopentyl]methanol (ROCKYPhos, CatASium I®), a camphor-derived chiral diphosphine ligand, has been developed. The key improvement in the synthetic scheme involved the oxidative cleavage...

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Príomhchruthaitheoir: Vitalii A. Bilenko
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: National University of Pharmacy (Kharkiv) 2026-04-01
Sraith:Журнал органічної та фармацевтичної хімії
Ábhair:
Rochtain ar líne:https://ophcj.nuph.edu.ua/article/view/353838
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