Rabbits transgenic for human IgG genes recapitulating rabbit B-cell biology to generate human antibodies of high specificity and affinity

Transgenic animals incorporating human antibody genes are extremely attractive for drug development because they obviate subsequent antibody humanization procedures required for therapeutic translation. Transgenic platforms have previously been established using mice, but also more recently rats, ch...

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Detalhes bibliográficos

Principais autores:	Francesca Ros, Sonja Offner, Stefan Klostermann, Irmgard Thorey, Helmut Niersbach, Sebastian Breuer, Grit Zarnt, Stefan Lorenz, Juergen Puels, Basile Siewe, Nicole Schueler, Tajana Dragicevic, Dominique Ostler, Imke Hansen-Wester, Valeria Lifke, Brigitte Kaluza, Klaus Kaluza, Wim van Schooten, Roland Buelow, Alain C Tissot, Josef Platzer
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2020-01-01
coleção:	mAbs
Assuntos:	Rabbit human immunoglobulins IgG transgenic immune repertoire gene conversion
Acesso em linha:	https://www.tandfonline.com/doi/10.1080/19420862.2020.1846900
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