P081 | EVALUATION OF PTPN11 MUTATION SUBTYPES AND THEIR POTENTIAL IMPACT ON CLINICAL OUTCOMES: A SINGLE-CENTER EXPERIENCE.

Background: PTPN11mutations can be found in 1.5%–12% of AML cases. They have been reported to cluster mainly in the N-terminal Src homology region 2 (N-SH2) and phosphatase (PTP) domains. Mutations in both domains remove the autoinhibition of the protein, leading to alterations in the RAS/MAPK path...

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主要な著者:	F. Crupi, G. Ciolli, M. Piccini, B. Scappini, L. Fasano, E. Quinti, A. Pasquini, J. Caroprese, N. Bartalucci, A. Enderti, C. Maccari, G. Rotunno, L. Signori, P. Guglielmelli, A.M. Vannucchi, F. Mannelli
フォーマット:	Artigo
言語:	Inglês
出版事項:	Ferrata Storti Foundation 2025-09-01
シリーズ:	Haematologica
オンライン･アクセス:	https://haematologica.org/article/view/12478
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