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TREK-1 and epilepsy: regulating the balance of K+ and the glutamate release in astrocyte-neuron interactions

Abstract The TWIK-related K+ channel (TREK-1), a member of the two-pore domain potassium(K2P) family, is characterized as a “leaky potassium channel” and is integral to the maintenance of the resting membrane potential. As the most abundant cell type in the central nervous system, astrocytes play im...

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Autors principals: Jianing Yang, Li Li, Yanan Xu, Yuguang Guan, Xiaoli Li
Format: Artigo
Idioma:Inglês
Publicat: BMC 2025-08-01
Col·lecció:Behavioral and Brain Functions
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Accés en línia:https://doi.org/10.1186/s12993-025-00294-x
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